Professor, Molecular & Integrative Physiology
Professor, Obstetrics & Gynecology
Director, Neuroscience Graduate Program
Director, Michigan Mouse Metabolic Phenotyping Center
MMPC-Live, NIDDK National Center
Michigan Neuroscience Institute Affiliate
Elizabeth W. Caswell Diabetes Institute
Research Investigator
My main research interest is to explore the neuronal networks integrating internal or external environmental signals to the reproductive and metabolic functions. In my current position, I am focused on characterizing the role of different cell populations of the hypothalamic ventral premammillary nucleus (PMv) on the neuroendocrine control of reproduction. For this purpose, I am using genetically modified mouse models, reproductive and metabolic phenotyping, transcriptome analysis and novel genetic and molecular tools (including viral vectors and CRISPR/Cas9).
In my independent research project, funded by MNORC and NICHD, I am exploring how environmental factors during pregnancy affect the development of hypothalamic networks involved in the control of metabolism and reproduction.
Postdoctoral Fellow
My research is focused on identifying the neural circuitry and molecular pathways that are involved in metabolic control of puberty and reproduction. Among the populations that have a role in this pathway, my main focus is on leptin receptor neurons, calcitonin receptor neurons and Kiss1 neurons in the ventral premammillary and the arcuate nuclei of the hypothalamus.
PhD candidate
adanku@umich.edu
One challenge in the field of reproduction is parsing out the mechanism behind abnormal migration of cells that produce Gonadotropin Releasing Hormone (GnRH) during development. This molecule drives fertility in humans but the mechanism behind its successful migration to the hypothalamus is not well understood. In pediatric incidences of Kallmann's syndrome (KS), a disease that causes infertility, patients often express coincident mutations in GnRH and Prokineticin Receptor 2 (PROKR2). In my research, I hope to describe the fertility implications of PROKR2 inhibition during development and report any consequential changes to GnRH migration.
Research manager, University of Georgia, GA
Fellow, Public Policy, CA
Postdoctoral fellow, University of Michigan
Laboratory manager, Wayne State university, MI
Clinical Assistant Professor, University of Michigan
Research Scientist, Wayne State University, MI
Assistant Professor, University of Córdoba, Spain
Biotech Industry, Consultant
Assistant Professor, Sichuan Agricultural University, China
Assistant Research Scientist, University of Michigan.
Biotech Industry
Medical student at Baylor College
Boston IVF Clinic - The Albany Center
Medical Student at Wayne State University
Biotech Industry
Postdoctoral fellow, University of São Paulo
Research Assistant, University of Texas Southwestern Medical Center
Ph.D. Candidate at Universidade Estadual de Campinas, Brazil
Federal University of Sao Paulo (UNIFESP), Brazil
Ph.D. Candidate at Universidade Estadual de Campinas, Limeira, Brazil
Postdoctoral Fellow, University of Sao Paulo, Brazil
Associate Professor at Universidade Federal do Espírito Santo, Espírito Santo, Brazil
Associate Professor at Universidade Estadual de Campinas, Limeira, Brazil
Graduate Student, University of Alberta, Canada
University of São Paulo, Ribeirão Preto, Brazil